We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Since its founding in 1943, Medievalia et Humanistica has won worldwide recognition as the first scholarly publication in America to devote itself entirely to medieval and Renaissance studies. Since 1970, a new series, sponsored by the Modern Language Association of America and edited by an international board of distinguished scholars and critics, has published interdisciplinary articles. In yearly hardbound volumes, the new series publishes significant scholarship, criticism, and reviews treating all facets of medieval and Renaissance culture: history, art, literature, music, (...) science, law, economics, and philosophy. (shrink)

As is the case with most pre‐modern philosophers of India, very little historical information is available about Bhartṛ‐hari. There are many interesting legends, some turned into extensive plays and poems, current about him. However, it is impossible to determine on their basis even whether there was only one philosopher called Bhartṛ‐hari. The appellation “philosopher” could unquestionably be applied to the author or authors of at least two Sanskrit works that are commonly ascribed to Bhartṛ‐hari.

Philosophers have recently revived the study of the ancient Greek topics of virtue and the virtues—justice, honesty, temperance, friendship, courage, and so on as qualities of mind and character belonging to individual people. But one issue at the center of Greek moral theory seems to have dropped out of consideration. This is the question of the unity of virtue, the unity of the virtues. Must anyone who has one of these qualities have others of them as well, indeed all of (...) them—all the ones that really do deserve to be counted as virtues? Even further, is there really no set of distinct and separate virtuous qualities at all, but at bottom only a single one—so that the person who has this single condition of “virtue” is entitled also to the further descriptions “honest” and “well-controlled” and “just” and “friendly” and “courageous” and “fostering” and “supportive,” and so on, as distinguishable aspects or immediate effects of his unitary “virtue”? (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...) access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. (shrink)

American health care is in the process of a significant social, institutional, and economic restructuring of the manner in which health services are provided in local communities. The Catholic health care ministry is undergoing the same sort of restructuring. The history of American health care demonstrates that the ministry has experienced at least two similar major restructurings of its institutional framework. The principle of cooperation has been the customary tool to assess the moral propriety of evolving social structures in which (...) the health care ministry has been housed. A process of discernment can lead to the conclusion that the central issue is not moral agency but rather how the ministry engages the secular culture of American society and American medicine. National Catholic Bioethics Quarterly 13.2 (Summer 2013): 263–274. (shrink)

According to many in the West, the liberalizing effects of North America’s free market ideals will generate equality and justice worldwide. I hold that we should be critical of those who justify imposing liberal democratic ideals on underdeveloped nations by simply suggesting that they promote equality and justice. In the West, entrenched disparities have shaped liberal ideals in ways that make inequality and injustice look natural and normal. Indeed, gender, class, and racial oppression have existed right alongside liberal democratic ideals. (...) If liberal ideals can be molded to make inequality and injustice look natural and normal in the West, then these same ideals can justify economic interactions, technology transfers, military cooperation, and mutual benefit agreements that sustain global inequality and injustice. (shrink)

The paper deals briefly with several definitional issues; discusses the concept of image as it determines the way managers see the world; as one aspect of the image, examines the contrasting views of conflict and cooperation in social and organizational relationships; and then presents a typology of corporate responses to pressures for socially responsible behavior: authoritarian, manipulative and bargaining. This typology was developed on the basis of the analysis of a large number of case histories of environmental conflicts, a number (...) of which are included for purposes of illustration. Several historical examples are cited. The inference drawn from this study is that decisions become more responsible as decision-makers come under the scrutiny of and pressure from those affected by the decisions. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

This book is a sustained examination of issues in the philosophy of ecology that have been a source of controversy since the emergence of ecology as an explicit scientific discipline. The controversies revolve around the idea of a balance of nature, the possibility of general ecological knowledge and the role of model-building in ecology. The Science of the Struggle for Existence is also a detailed treatment of these issues that incorporates both a comprehensive investigation of the relevant ecological literature and (...) the development of an explicit theoretical framework in the philosophy of science. It addresses issues in the philosophy of ecology that are of particular importance for the deployment of ecology in the solution of environmental problems. It will have a cross-disciplinary appeal and will interest students and professionals in science, the philosophy of science, and environmental studies as well as policy-makers. (shrink)

Recent scholarship has steadily been opening up for philosophical study an increasingly wide range of the philosophical literature of antiquity. We no longer think only of Socrates, Plato and Aristotle, and their pre-Socratic forebears, when someone refers to the views of the ancient philosophers. Julia Annas has been one of the philosophers most closely engaged in the renewed study of Hellenistic philosophy over the past fifteen years, enabling herself and other scholars to acquire the necessary ground-level knowledge of the widely-dispersed (...) texts and the problems of interpretation—both historical and philosophical—that they present. In her new book she takes the next step. She presents to the general philosophical public of today an extended reconstruction of the systems of moral philosophy that were developed and pitted in competition with one another during the period when refinement and professionalism were at their height in Greek philosophy—between the end of the 4th and the middle of the 1st centuries B.C. These include the moral philosophies of Epicurus and his followers, several generations of Stoics, sceptical philosophers both Academic and Pyrrhonian, and the “hybrid” theories put together by Antiochus of Ascalon and other Stoic-influenced philosophers as part of the modernizing revival of Aristotelian ethical thought that took place in the 1st century B.C. She finds significant commonalities among these otherwise very disparate theories, and much of the book is devoted to examining these and showing how the conception of ethics and morality that is common to the ancient theorists compares with and differs from what we are familiar with in modern and contemporary theory. She traces these commonalities back to Aristotle in his ethical treatises, and accordingly includes Aristotle’s theory as one among those to be examined—indeed, in a significant sense as the intellectual father or grandfather of the rest of them. She leaves Plato’s dialogues out of account, and she has nothing to say about ethics and moral philosophy in the revived Platonism that gradually came to dominate philosophical thought in later antiquity. Her book, then, is a book about the structure and content of ancient ethical theory during the Hellenistic period, the period when Greek philosophy was at its high-point in professionalism and sophistication. (shrink)

Knowledge, Nature, and the Good brings together some of John Cooper's most important works on ancient philosophy. In thirteen chapters that represent an ideal companion to the author's influential Reason and Emotion, Cooper addresses a wide range of topics and periods--from Hippocratic medical theory and Plato's epistemology and moral philosophy, to Aristotle's physics and metaphysics, academic scepticism, and the cosmology, moral psychology, and ethical theory of the ancient Stoics.Almost half of the pieces appear here for the first (...) time or are presented in newly expanded, extensively revised versions. Many stand at the cutting edge of research into ancient ethics and moral psychology. Other chapters, dating from as far back as 1970, are classics of philosophical scholarship on antiquity that continue to play a prominent role in current teaching and scholarship in the field. All of the chapters are distinctive for the way that, whatever the particular topic being pursued, they attempt to understand the ancient philosophers' views in philosophical terms drawn from the ancient philosophical tradition itself.Through engaging creatively and philosophically with the ancient texts, these essays aim to make ancient philosophical perspectives freshly available to contemporary philosophers and philosophy students, in all their fascinating inventiveness, originality, and deep philosophical merit. This book will be treasured by philosophers, classicists, students of philosophy and classics, those in other disciplines with an interest in ancient philosophy, and anyone who seeks to understand philosophy in philosophical terms. (shrink)

I Deliberation, Practical Syllogisms , and Intuition. Introduction Aristotle's views on moral reasoning are a difficult and much disputed subject. ...

We shall argue that there is adequate moral justification for capital punishment with linkage, that is, with linkage to keeping non-murderers from dying. We present the argument with two aims in mind. The first is to question the conventional wisdom, seldom challenged even by proponents of capital punishment, that being an abolitionist is closely connected to having a civilized respect for human life. This conventional wisdom, we hope to show, is somewhat off the mark. To this end we exhibit structural (...) similarities between so-called lifeboat dilemmas and the public's relationship to a murderer. In a lifeboat dilemma one must choose between saving this life or that, since the lifeboat will not hold both persons. Now if this life were an innocent's and that one a murderer's, a choice to save the latter would not be met with accusations of callousness towards human life. We hope to project everyone's intuitions about this case onto the more baffling case of a society's relationship to the murderers and dying innocents in its midst. (shrink)

NEITHER in the scholarly nor in the philosophical literature on Aristotle does his account of friendship occupy a very prominent place. I suppose this is partly, though certainly not wholly, to be explained by the fact that the modern ethical theories with which Aristotle’s might demand comparison hardly make room for the discussion of any parallel phenomenon. Whatever else friendship is, it is, at least typically, a personal relationship freely, even spontaneously, entered into, and ethics, as modern theorists tend to (...) conceive it, deals rather with the ways in which people are required to regard, and behave toward, one another, than with the organization of their private affairs. To the extent, then, that one shares this modern outlook one will tend to neglect, or treat merely as an historical curiosity, Aristotle’s efforts to define friendship and to place it within the framework of human eudaimonia, the theory of which is central to moral philosophy as he understands it. Yet in the Nicomachean Ethics the two books on φιλία make up nearly a fifth of the whole, and this seems to me a fair measure of the importance of this subject to the complete understanding both of Aristotle’s overall moral theory and even of many of the more circumscribed topics to which so much scholarly and philosophical attention has been devoted. If, as I suggest, the failure of commentators to appreciate its importance is partly the effect of distortions produced by the moral outlook that has predominated in modern moral philosophy, the careful study of these books may help to free us from constricting prejudices and perhaps even make it possible to discover in Aristotle a plausible and suggestive alternative to the theories constructed on the narrower base characteristic of recent times. (shrink)

I discuss the division of the soul in plato's "republic". i concentrate on the arguments and illustrative examples given in book iv, but i treat the descriptions of different types of person in viii-ix and elsewhere as further constituents of a single, coherent theory. on my interpretation plato distinguishes three basic kinds of motivation which he claims all human beings regularly experience in some degree. reason is itself the immediate source of certain desires. in addition, there are appetitive and also--quite (...) distinct from either of the other two--competitive motivations. (shrink)

Situation Theory grew out of attempts by Jon Barwise in the late 1970s to provide a semantics for 'naked-infinitive' perceptual reports such as 'Claire saw Jon run'. Barwise's intuition was that Claire didn't just see Jon, an individual, but Jon doing something, a situation. Situations are individuals having properties and standing in relations. A theory of situations would allow us to study and compare various types of situations or situation-like entitles, such as facts, events, and scenes. One of the central (...) themes of situation theory of meaning and reference should be set within a general theory of information, one moreover that is rich enough to do justice to perception, communication, and thought. By now many people have contributed by the need to give a rigorous mathematical account of the principles of information that underwrite the theory. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Nature in Nineteenth-Century British Novels:Doing the MathJoseph Carroll, Jonathan Gottschall, John A. Johnson, and Daniel J. KrugerIThree broad ambitions animate this study. Building on research in evolutionary social science, we aimed (1) to construct a model of human nature—of motives, emotions, features of personality, and preferences in marital partners; (2) use that model to analyze some specific body of literary texts and the responses of readers to (...) those texts, and (3) produce data—information that could be quantified and could serve to test specific hypotheses about those texts.Evolutionary social science is still in the process of constructing a full and adequate model of human nature. Evolutionary social scientists know much already about how human reproductive behavior and human sociality fit into the larger pattern of human evolution. They still have much to learn, though, about the ways literature and the other arts enter into human nature. Our model of human nature draws on our knowledge of imaginative culture, integrates that knowledge with evolutionary theories of culture, and produces data that enable us to draw conclusions on an issue of broad significance for both literary study and evolutionary social science: the adaptive function of literature and the other arts.1In order to make advances in knowledge, it is necessary to choose some particular subject. Genetics is a basic science that applies to all organisms, but geneticists first got an empirical fix on their subject by focusing minutely, with Mendel, on peas, and, with Morgan, on fruit flies. In place of peas and flies, we have taken as our subject British novels of [End Page 50] the longer nineteenth century (Austen to Forster). As a literary topic, the subject is fairly broad, but our theoretical and methodological aims ultimately extend well beyond the specialist fields of British novels, the nineteenth century, British literature, narrative fiction, or even literary scholarship generally. This study is designed to engage the attention of literary scholars in all fields and also to engage the attention of social scientists. If it achieves its aims, this study would help persuade literary scholars that empirical methods offer rich opportunities for the advancement of knowledge about literature, and it would help persuade social scientists that the quantitative study of literature can shed important light on fundamental questions of human psychology and human social interaction. Our own research team combines these two prospective audiences. Two of us (Carroll and Gottschall) have been trained primarily as literary scholars, and two of us (Johnson and Kruger) primarily as social scientists.The focal point for this study is "agonistic" structure: the organization of characters into protagonists, antagonists, and minor characters. The central question in the study is this: does agonistic structure reflect evolved dispositions for forming cooperative social groups? Suppressing or muting competition within a social group enhances group solidarity and organizes the group psychologically for cooperative endeavor. Our chief hypothesis was that protagonists and good minor characters would form communities of cooperative endeavor and that antagonists would exemplify dominance behavior. If this hypothesis proved correct, the ethos reflected in the agonistic structure of the novels would replicate the egalitarian ethos of hunter-gatherers, who stigmatize and suppress status-seeking in potentially dominant individuals. If suppressing dominance in hunter-gatherers fulfills an adaptive social function, and if agonistic structure in the novels engages the same social dispositions that animate hunter-gatherers, our study would lend support to the hypothesis that literature fulfills an adaptive social function.2One of our chief working hypotheses is that when readers respond to characters in novels, they respond in much the same way, emotionally, as they respond to people in everyday life. They like or dislike them, admire them or despise them, fear them, feel sorry for them, or are amused by them. In writing fabricated accounts of human behavior, novelists select and organize their material for the purpose of generating such responses, and readers willingly cooperate with this purpose. They participate vicariously in the experiences depicted and form personal opinions about the qualities of the characters. Authors and readers [End Page 51] thus collaborate in producing a simulated experience of emotionally responsive evaluative judgment. If agonistic structure is a... (shrink)

This paper addresses central issues in the debate about inclusive language for God by responding to Andrew Dell’Olio, who offered biblical, theological, linguistic, and ethical reasons for a “supplemental” use of feminine language for God. Since he leaves unclear whether “supplemental” means “secondary to” or “fully equal to” the masculine language of the biblical tradition, it is difficult to determine whether he makes his case. While a secondary role for feminine language for God is legitimate, I argue that giving feminine (...) language a status equal to the Bible’s masculine language for God is not warranted by the standard biblical and theological criteria of the Christian tradition. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Nature in Nineteenth-Century British Novels:Doing the MathJoseph Carroll, Jonathan Gottschall, John A. Johnson, and Daniel J. KrugerIThree broad ambitions animate this study. Building on research in evolutionary social science, we aimed (1) to construct a model of human nature—of motives, emotions, features of personality, and preferences in marital partners; (2) use that model to analyze some specific body of literary texts and the responses of readers to (...) those texts, and (3) produce data—information that could be quantified and could serve to test specific hypotheses about those texts.Evolutionary social science is still in the process of constructing a full and adequate model of human nature. Evolutionary social scientists know much already about how human reproductive behavior and human sociality fit into the larger pattern of human evolution. They still have much to learn, though, about the ways literature and the other arts enter into human nature. Our model of human nature draws on our knowledge of imaginative culture, integrates that knowledge with evolutionary theories of culture, and produces data that enable us to draw conclusions on an issue of broad significance for both literary study and evolutionary social science: the adaptive function of literature and the other arts.1In order to make advances in knowledge, it is necessary to choose some particular subject. Genetics is a basic science that applies to all organisms, but geneticists first got an empirical fix on their subject by focusing minutely, with Mendel, on peas, and, with Morgan, on fruit flies. In place of peas and flies, we have taken as our subject British novels of [End Page 50] the longer nineteenth century (Austen to Forster). As a literary topic, the subject is fairly broad, but our theoretical and methodological aims ultimately extend well beyond the specialist fields of British novels, the nineteenth century, British literature, narrative fiction, or even literary scholarship generally. This study is designed to engage the attention of literary scholars in all fields and also to engage the attention of social scientists. If it achieves its aims, this study would help persuade literary scholars that empirical methods offer rich opportunities for the advancement of knowledge about literature, and it would help persuade social scientists that the quantitative study of literature can shed important light on fundamental questions of human psychology and human social interaction. Our own research team combines these two prospective audiences. Two of us (Carroll and Gottschall) have been trained primarily as literary scholars, and two of us (Johnson and Kruger) primarily as social scientists.The focal point for this study is "agonistic" structure: the organization of characters into protagonists, antagonists, and minor characters. The central question in the study is this: does agonistic structure reflect evolved dispositions for forming cooperative social groups? Suppressing or muting competition within a social group enhances group solidarity and organizes the group psychologically for cooperative endeavor. Our chief hypothesis was that protagonists and good minor characters would form communities of cooperative endeavor and that antagonists would exemplify dominance behavior. If this hypothesis proved correct, the ethos reflected in the agonistic structure of the novels would replicate the egalitarian ethos of hunter-gatherers, who stigmatize and suppress status-seeking in potentially dominant individuals. If suppressing dominance in hunter-gatherers fulfills an adaptive social function, and if agonistic structure in the novels engages the same social dispositions that animate hunter-gatherers, our study would lend support to the hypothesis that literature fulfills an adaptive social function.2One of our chief working hypotheses is that when readers respond to characters in novels, they respond in much the same way, emotionally, as they respond to people in everyday life. They like or dislike them, admire them or despise them, fear them, feel sorry for them, or are amused by them. In writing fabricated accounts of human behavior, novelists select and organize their material for the purpose of generating such responses, and readers willingly cooperate with this purpose. They participate vicariously in the experiences depicted and form personal opinions about the qualities of the characters. Authors and readers [End Page 51] thus collaborate in producing a simulated experience of emotionally responsive evaluative judgment. If agonistic structure is a... (shrink)

Philosophers have recently revived the study of the ancient Greek topics of virtue and the virtues—justice, honesty, temperance, friendship, courage, and so on as qualities of mind and character belonging to individual people. But one issue at the center of Greek moral theory seems to have dropped out of consideration. This is the question of the unity of virtue, the unity of the virtues. Must anyone who has one of these qualities have others of them as well, indeed all of (...) them—all the ones that really do deserve to be counted as virtues? Even further, is there really no set of distinct and separate virtuous qualities at all, but at bottom only a single one—so that the person who has this single condition of “virtue” is entitled also to the further descriptions “honest” and “well-controlled” and “just” and “friendly” and “courageous” and “fostering” and “supportive,” and so on, as distinguishable aspects or immediate effects of his unitary “virtue”? (shrink)

This is an interesting addition to the history of philosophy generally and an incredible expansion of the history of Idealistic philosophy in particular. The subject is John Scottus Eriugena, a ninth century philosopher and member of The Carolingian intellectual renewal, who, claims Dermot Moran, developed a form of idealism that owed as much, or more, to the Greek neo-platonic tradition as to St. Augustine. Eriugena’s thought anticipated the priority of the subject in the radical way that most scholars believe (...) originated only a thousand years later in German Idealism. Moran, of St. Patrick’s College in Maynooth, Ireland, bases these fascinating claims on an analysis of Eriugena’s most important work, The Periphyseon, or the fourfold division of nature, completed around 867 A.D. (shrink)

_A new theory of how and why we cooperate, drawing from economics, political theory, and philosophy to challenge the conventional wisdom of game theory_ Game theory explains competitive behavior by working from the premise that people are self-interested. People don’t just compete, however; they also cooperate. John Roemer argues that attempts by orthodox game theorists to account for cooperation leave much to be desired. Unlike competing players, cooperating players take those actions that they would like others to take—which Roemer (...) calls “Kantian optimization.” Through rigorous reasoning and modeling, Roemer demonstrates a simpler theory of cooperative behavior than the standard model provides. (shrink)

As it is currently understood, the notion of autonomy, both as something that belongs to human beings and human nature, as such, and also as the source or basis of morality , is bound up inextricably with the philosophy of Kant. The term “autonomy” itself derives from classical Greek, where it was applied primarily or even exclusively in a political context, to civic communities possessing independent legislative and self-governing authority. The term was taken up again in Renaissance and early modern (...) times with similar political applications, but was applied also in ecclesiastical disputes about the independence of reformed churches from the former authority in religious matters of the church of the Roman popes. Kant's innovation consisted in conceiving of individual rational persons, as such, as lawgivers or legislators to themselves, and to all rational beings , for their individual modes of behavior. For Kant, rational beings possess a power of legislating for themselves individually, according to which they each set their own personal ends and subject that selection, and their pursuit of the ends in question, to a universal principle, which is expressed in Kant's categorical imperative. The categorical imperative requires that one set one's own ends only within a framework that would warrant acceptance by all other such beings. (shrink)

Originally published in 1990. This book discusses in a philosophically responsible and illuminating way the progress of the dialogue and its separate sections to improve our understanding of Plato’s work on Theaetetus. An early coverage of this dialogue, this investigation predated a surge in study of Plato’s piece which examined Socratic and pre-Socratic thought. The author’s argument is that the _Theaetetus_ engages in re-evaluation of earlier doctrines of middle-period Platonism as well as reaffirming theories about knowledge. An important work in (...) Platonic studies and epistemology. (shrink)

This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotransplantation into the clinical setting. The symposium was the first of its kind in the UK for 20 years. This paper (...) summarises the content of the expert lectures showcasing the progress which has been made in xenotransplantation including—the history of xenotransplantation, advances in gene edited animals and progress towards clinical xenotransplantation. We then set out the ethical and legal issues still to be resolved. Finally, we report the themes of the roundtable discussion highlighting areas of consensus and controversy. While the detail of the legal discussion was directed towards the UK, the principles and summary reported here are intended to be applicable to any jurisdiction seeking to implement clinical xenotransplantation. (shrink)

My ultimate purpose here is to examine, discuss, and interpret a difficult excerpt in Stobaeus’ 5th c. AD anthology, alleging to report—uniquely, it appears—a distinction Chrysippus drew between three different applications of the term stoixe›on or element (i.e., physical element).1 Stobaeus lists this passage as giving opinions specifically of Chrysippus “about the elements out of substance” (per‹ t«n §k t∞w oÈs€aw stoixe€vn), though in holding them he says Chrysippus was following Zeno, the leader of his sect. Hermann Diels (1879) identified (...) this selection as an excerpt (his fr. 21) from Arius Didymus’ late first century BC Epitome of Physical Doctrines.2 I print a translation below, with the text in an Appendix, as it is given in von Arnim (1903). The text is not without its problems, and I indicate in footnotes to the text which of the principal editors’ textual interventions I accept and follow in my translation. Whether this text presents a single, continuous excerpt from Arius Didymus, or instead some compilation of Stobaeus (or an earlier anthologist whose work Stobaeus employed) from dispersed passages of.. (shrink)

The ancient Stoics notoriously argued, with thoroughness and force, that all ordinary “emotions” (passions, mental affections: in Greek, pãyh) are thoroughly bad states of mind, not to be indulged in by anyone, under any circumstances: anger, resentment, gloating; pity, sympathy, grief; delight, glee, pleasure; impassioned love (i.e. ¶rvw), agitated desires of any kind, fear; disappointment, regret, all sorts of sorrow; hatred, contempt, schadenfreude. Early on in the history of Stoicism, however, apparently in order to avoid the objection that human nature (...) itself demands and indeed justifies—under certain circumstances at any rate—emotional attachments to or aversions from, and reactions to, some persons, things, and happenings, they introduced a theory of what came to be called eÈpãyeiai, good and acceptable ways of feeling or being affected. For short I will render these in English by “good feelings.”1 They divided these into three generic kinds, which they dubbed “joy” (xarã), “wish” (boÊlhsiw) and “caution” (eÈlãbeia). They ranged these alongside, and set them in sharp contrast to, three of the four highest genera into which they divided the normal human emotions: “pleasure” (≤donÆ), i.e., being pleased about something,2 “appetitive desire” (§piyuµ€a), and “fear” (fÒbow), respectively. The Stoics maintained that, though ordinary, familiar human emotions such as these last-named ones were always bad, the three sorts of “good feeling,” and their more specific variations (since these three are only the basic genera into which lots of other good ways of feeling will fall), were not merely free from the grounds of criticism on which ordinary emotions were rejected, and so were perfectly acceptable. The fully perfected human being (the “wise person”) would indeed regularly be subject to them.3 Their theory of the perfect human life did not, then, they could claim, require any outrageously unnatural demand, presumably unrealizable in any case, for a life completely without all feelings of involvement in the sweep and flow of life.. (shrink)

This six volume Routledge Library Edition set is dedicated to the work of key nineteenth-century German thinker, Friedrich Nietzsche, whose hugely influential work in the field of philosophy continues to be felt to this day. The six volumes, published between 1948 and 1988, represent a truly wide-ranging analysis of Nietzsche’s life and work, offering an excellent overview of the cannon of critical analysis and interpretation on Nietzsche in the twentieth century. The collection covers Nietzsche’s perspectives and influence upon a variety (...) of sociological and philosophical debates, as well as placing his work in the context of contemporaries such as Richard Wagner, Fyodor Dostoyevsky and Max Stirner. (shrink)

The first part of the chapter translates and discusses, section by section, Metaphysics Α 10. The second part rveiews in retrospect Aristotle's intentions in Metaphysics Α as a whole, and the progress of his argument through the 10 chapters of the book. It is Aristotle's intention to search for the first principles and causes of being, by reviewing and examining the opinions of his predecessors on this subject. A distinction must be made between Aristotle's report of his predecessors' opinions and (...) his critical discussion of the difficulties he thinks their views involve; at the end of the book Aristotle reminds us that we need to mull over these difficulties for ourselves: this is the programme set for Book B. (shrink)

Originally published in 1990. This book discusses in a philosophically responsible and illuminating way the progress of the dialogue and its separate sections to improve our understanding of Plato’s work on Theaetetus. An early coverage of this dialogue, this investigation predated a surge in study of Plato’s piece which examined Socratic and pre-Socratic thought. The author’s argument is that the Theaetetus engages in re-evaluation of earlier doctrines of middle-period Platonism as well as reaffirming theories about knowledge. An important work in (...) Platonic studies and epistemology. (shrink)

This paper describes the application of eight statistical and machine-learning methods to derive computer models for predicting mortality of hospital patients with pneumonia from their findings at initial presentation. The eight models were each constructed based on 9847 patient cases and they were each evaluated on 4352 additional cases. The primary evaluation metric was the error in predicted survival as a function of the fraction of patients predicted to survive. This metric is useful in assessing a model’s potential to assist (...) a clinician in deciding whether to treat a given patient in the hospital or at home. We examined the error rates of the models when predicting that a given fraction of patients will survive. We examined survival fractions between 0.1 and 0.6. Over this range, each model’s predictive error rate was within 1% of the error rate of every other model. When predicting that approximately 30°K of the patients will survive, all the models have an error rate of less than 1.5%. The models are distinguished more by the number of variables and parameters that they contain than by their error rates; these differences suggest which models may be the most amenable to future implementation as paper-based guidelines. (shrink)

Christians who affirm standard science and the biblical doctrine of creation often endorse theistic evolution as the best approach to human origins. But theistic evolution is ambiguous. Some versions are naturalistic (NTE)—God created humans entirely by evolution—and some are supernaturalistic (STE)—God supernaturally augmented evolution. This article claims that NTE is inadequate as an account of human origins because its theological naturalism and emergent physicalist ontology of the soul or person conflict with the Christian doctrine that God created humans for everlasting (...) life. Both the traditional Christian account of the afterlife and its modern Christian alternatives involve God's supernatural action and a separation (dualism) of person and body at death. STE can combine with several philosophical accounts of the body-soul relation to provide an adequate Christian account of original human nature. (shrink)

If now we turn to the recent translation of the Politics by Carnes Lord we see that the language of "rights" is completely avoided. Lord prefers to speak sometimes in terms of what a person or group of persons is "entitled to" under the laws, or of what is "open" or "permitted" to them; and he usually or always sticks to "justice" or a related term to translate δίκαιον and its derivatives--whether this is justice as established by the laws of (...) a given community or type of community, or the true or correct account of what justice is and demands. It is doubtful, though, whether Lord avoids rights-talk as a matter of interpretative principle. He aims to translate key terms of the Greek with a single English translation throughout, with the result that, since in any event Aristotle uses no single Greek term where we might be tempted to speak of rights, avoiding the language of rights may have seemed to him required simply by his conception of "literal" translation. In his glossary under the heading "Justice," he explicates τὸ δίκαιον in part as "a right or rightful claim" and adds that this sense is generally rendered in his translation by "[claim to] justice." So, if we take this glossary entry as giving his full view, Lord would not object to at least interpreting Aristotle in these passages as speaking of rights or rightful claims. However, Lord is a follower of Leo Strauss and in his avoidance of the noun "right" to render anything Aristotle says, he may also have been falling in with Strauss's own considered view, which was that any attribution of a notion of "rights" to Aristotle or any other ancient thinker is so grossly anachronistic that it must be strictly avoided. In the past forty years or so I think it is fair to say that this view of Strauss's has been shared increasingly by important writers on ancient politics and political thought. Perhaps this tendency is all the more prevalent with the onset of self-described "post-modernist" thought and the historicism in all interpretation of the past that it so often connotes. Is there anything to this objection of vicious anachronism? Were Barker and other older writers making a serious error in rendering and interpreting Aristotle so as to make him hold theories about various ancient constitutions as granting political and other legal rights to people living under them, and also theories of his own about the rights people have under justice as to what their political and legal rights shall be? A major thesis of Fred Miller's recent book, Nature, Justice, and Rights in Aristotle's Politics is that they were not--at least they were not, once certain distinctions are carefully drawn, and one is careful to state what is and what is not implied by the "rights" talk they were so readily finding in Aristotle's texts. In what follows I will limit myself to discussing this thesis of Miller's and his handling of it. (shrink)

The Nicomachean Ethics announces itself as a treatise on the highest human good, the “end” (t°low) of human life—eÈdaiµon€a or happiness. In the last chapter of the work (X 9) Aristotle makes it clear that the study of the happy lives of contemplation and political leadership, the virtues, friendship, and pleasure that has by then been carried out in investigating that good—these are the leading themes of the Ethics that he mentions there (1179a33-35)— leaves the treatise’s objectives not yet completely (...) achieved. He began the work by saying (I 1- 2) that the study it contains is intended as a contribution to “political knowledge” (politikØ §pistƵh) or the political capacity or power (dÊnaµiw).1 Its work will not be complete, he now says, until a successful reader (or hearer) has been brought actually to possess that knowledge or power—political knowledge, that is, the fully accomplished capacity for expert political engagement in affairs of state. In effect, the reader of the Nicomachean Ethics needs now to learn, further, the subjects of study to which Aristotle’s own Politics is devoted. Before the aim announced at the beginning of the Ethics can be achieved—that is, before we can fully define and explain in the right sort of way the highest human good, or eÈdaiµon€a (I’ll say more in just a moment about what this right sort of way is)—we need, as he puts it in NE X 9 (1180a32 ff.), to become expert in the establishment of good laws (noµoyetikÆ) and good constitutions (polite›ai, cf. 1181b14, 19, 21). One might find this a surprising claim. As Aristotle himself is in no doubt, eÈdaiµon€a is a feature of the lives of individual persons. On his account it is an activity, or a unified set of ac-. (shrink)